The billionaire refused to leave his retreat on Necker Island despite the threat of the incoming storm packing winds of 185mph.
He said he would be bunkering down with his team in a concrete wine cellar.
Now his son Sam Branson has confirmed no one was hurt on Necker.
Posting on Instagram he said: "Glad to say that all humans on Necker are ok although a lot of buildings destroyed."
Sam went on to say that his thoughts are with other Caribbean islands who have not fared as well.
"Very concerned for our friends and everyone on the neighbouring islands and people in its path," he added.
"Please don't take this hurricane lightly if it is heading your way.
"If your building is not very solid, do find somewhere safe! Homes can be rebuilt but lives can't."
Earlier, Richard Branson described his preparations for Irma.
"We are expecting to get the full force of the hurricane in around five hours’ time, when we will retreat to a concrete wine cellar under the Great House," Branson wrote on his blog.
"Knowing our wonderful team as I do, I suspect there will be little wine left in the cellar when we all emerge."
The business mogul added that everyone at the estate slept in just two rooms last night as they prepared for the extreme weather.